Purine nucleoside analogues: fludarabine, pentostatin, and cladribine
作者： Jill M. Kolesar , Ashley K. Morris , John G. Kuhn
DOI: 10.1177/107815529600200403
关键词: Fludarabine 、 Adenosine 、 Drug 、 Adverse effect 、 Cladribine 、 Pharmacology 、 Medicine 、 Pentostatin 、 Pharmacokinetics 、 Nucleoside 、 Pharmacology (medical) 、 Oncology
摘要: Purpose. The primary objective of this article is to continue the discussion pharmacology, phar macokinetics, clinical use, and adverse effects currently approved adenosine analogues, focusing on pentostatin. This part two a three series.Data Sources. We reviewed literature through MEDLINE search from 1986 1996. Rele vant articles cited in obtained by MED LINE searching also were considered. searched following terms: fludarabine, cladribine, pentosta tin, apoptosis, analogues. was restricted English language.Data Extraction. have current regard chemistry, mechanisms action pharmacokinetics, effects, drug interactions, indications, formulation, dosage, administration, pharmaceu tical issues adenosoine pentostatin.Data Synthesis. analogues are structurally similar agents used ...
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