A computational model based on fibrin accumulation for the prediction of stasis thrombosis following flow‑diverting treatment in cerebral aneurysms

作者: Chubin Ou , Wei Huang , Matthew Ming-Fai Yuen

DOI: 10.1007/S11517-016-1501-1

关键词: SurgeryCoagulationCardiologyAneurysmThrombusFibrinBlood flowThrombosisRight Common Carotid ArteryMedicineInternal medicineFlow (mathematics)

摘要: Flow diverters, the specially designed low porosity stents, have been used to redirect blood flow from entering aneurysm, which induces stasis in aneurysm and promote thrombosis for repairing aneurysm. However, it is not clear how thrombus develops following flow-diversion treatment. Our objective was develop a computation model prediction of stasis-induced treatment cerebral aneurysms. We proposed hypothesis initiate coagulation An experimental by ligating rat's right common carotid artery (RCCA) create flow-stasis environment. Thrombus formed RCCA as result stasis. The fibrin distributions different sections along axial length were measured. distribution predicted our computational displayed trend increase proximal neck distal tip, consistent with results on rats. applied saccular treated diverter investigate development diversion. form inside sac, occluded only small remnant remained. can serve tool evaluate outcome optimize design diverters.

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