Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach

摘要: Surgical valve replacement in patients with severe calcific aortic disease using either bioprosthetic or mechanical heart valves is still limited by structural deterioration for the former and thrombosis risk mandating anticoagulant therapy latter. Prosthetic polymeric have potential to overcome inherent material design limitations of these valves, but their development ongoing. The aim this study was characterize hemodynamics thrombogenic Polynova trileaflet prototype a fluid–structure interaction (FSI) approach. FSI model replicated experimental conditions as tested left simulator. Hemodynamic parameters (transvalvular pressure gradient, flow rate, maximum velocity, effective orifice area) were compared assess validity model. footprint evaluated Lagrangian approach calculate stress accumulation (SA) values along multiple platelet trajectories statistical distribution. In commissural regions, platelets exposed highest SA because levels combined local reverse patterns vortices. Stress-loading waveforms from representative regions interest emulated our hemodynamic shearing device (HSD). Platelet activity measured activation state (PAS) assay results confirmed higher hotspots. conclusion, proposed method provides an depth analysis performance polymer identifies locations further optimization.