Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
作者： Zhengyan Kan , Ying Ding , Jinho Kim , Hae Hyun Jung , Woosung Chung
DOI: 10.1038/S41467-018-04129-4
关键词: Cohort 、 Exome sequencing 、 BRCA2 Protein 、 Breast cancer 、 Carcinoma 、 Microdissection 、 Biology 、 Transcriptome 、 Cancer research 、 Tumor microenvironment
摘要: Breast cancer (BC) in the Asia Pacific regions is enriched younger patients and rapidly rising incidence yet its molecular bases remain poorly characterized. Here we analyze whole exomes transcriptomes of 187 primary tumors from a Korean BC cohort (SMC) pre-menopausal perform systematic comparison with primarily Caucasian post-menopausal (TCGA). SMC harbors higher proportions HER2+ Luminal B subtypes, lower proportion A decreased ESR1 expression compared to TCGA. We also observe increased mutation prevalence affecting BRCA1, BRCA2, TP53 an enrichment signature linked homologous recombination repair deficiency TNBC. Finally, virtual microdissection multivariate analyses reveal that status independently associated TIL TGF-β signaling signatures, suggesting Asian BCs harbor more immune-active microenvironment than western BCs.
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