Implication de la Lipocaline 2 dans les effets physiopathologiques du récepteur minéralocorticoïde dans le système cardiovasculaire.
作者： Antoine Tarjus
DOI:
关键词: Molecular biology 、 Medicine
摘要: Les pathologies cardiovasculaires sont la premiere cause de mortalite dans le monde. Parmi les mecanismes participant a ces figurent l'activation voie signalisation mineralocorticoide. Notre laboratoire precedemment identifie Lipocaline 2 (Lcn2) comme cible directe du complexe aldosterone/recepteur mineralocorticoide (RM) systeme cardiovasculaire. Lcn2, aussi appelee Neutrophil Gelatinase Associated Lipocalin (NGAL), est une proteine circulante, membre famille des lipocalines. Elle decrite l'inflammation ou regulant l'activite et stabilite metalloproteinase matricielle 9. L'objectif ce travail these d'etudier l'implication possible Lcn2 effets pathologiques pro-fibrosants pro-inflammatoires aldosterone/RM Pour faire, souris presentant inactivation globale constitutive (KO Lcn2), ainsi que leurs controles, ont ete soumises un traitement mimant sur-activation (traitement nephrectomie-aldosterone-sel) durant 4 semaines. Ce mis en evidence role developpement fibrose perivasculaire induite par aldo/RM l'augmentation pression arterielle. En revanche, n'intervient pas interstitielle ni dysfonction vasculaire. d'action differents phenomenes restent elucider. conclusion, resultats obtenus montrent l’implication au niveau cardiovasculaire, suggerant potentielle therapeutique
archives-ouvertes.fr参考文章(201)
Johann Bauersachs, Marina Heck, Daniela Fraccarollo, Steven K Hildemann, Georg Ertl, Martin Wehling, Michael Christ, Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: role of vascular superoxide anion formation and endothelial nitric oxide synthase expression. Journal of the American College of Cardiology. ,vol. 39, pp. 351- 358 ,(2002) , 10.1016/S0735-1097(01)01729-6
C G Brilla, K T Weber, Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. Journal of Laboratory and Clinical Medicine. ,vol. 120, pp. 893- 901 ,(1992)
Erfei Song, Hung-Fat Tse, Paul M Vanhoutte, Gary Sweeney, Aimin Xu, Karen Sl Lam, Jessie Ws Yue, Pengcheng Fan, Yu Wang, Bo Yang, Thorsten Berger, Tak W Mak, Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling American Journal of Translational Research. ,vol. 4, pp. 60- 71 ,(2012)
CHRISTINE TANAKA ESPOSITO, SUBHA VARAHAN, DARWIN JEYARAJ, YUAN LU, BRUCE S. STAMBLER, Spironolactone improves the arrhythmogenic substrate in heart failure by preventing ventricular electrical activation delays associated with myocardial interstitial fibrosis and inflammation. Journal of Cardiovascular Electrophysiology. ,vol. 24, pp. 806- 812 ,(2013) , 10.1111/JCE.12115
Yao Sun, Jiakun Zhang, Li Lu, Sue S. Chen, Mark T. Quinn, Karl T. Weber, Aldosterone-Induced Inflammation in the Rat Heart: Role of Oxidative Stress American Journal of Pathology. ,vol. 161, pp. 1773- 1781 ,(2002) , 10.1016/S0002-9440(10)64454-9
Jacky TC Liu, Erfei Song, Aimin Xu, Thorsten Berger, Tak W Mak, Hung-Fat Tse, Ivy KM Law, Bosheng Huang, Yan Liang, Paul M Vanhoutte, Yu Wang, Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition British Journal of Pharmacology. ,vol. 165, pp. 520- 531 ,(2012) , 10.1111/J.1476-5381.2011.01587.X
Rangaiah Shashidharamurthy, Deepa Machiah, Jesse D. Aitken, Kalyani Putty, Gayathri Srinivasan, Benoit Chassaing, Charles A. Parkos, Periasamy Selvaraj, Matam Vijay-Kumar, Differential Role of Lipocalin 2 During Immune Complex–Mediated Acute and Chronic Inflammation in Mice Arthritis & Rheumatism. ,vol. 65, pp. 1064- 1073 ,(2013) , 10.1002/ART.37840
L. Kjeldsen, A.H. Johnsen, H. Sengeløv, N. Borregaard, Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase Journal of Biological Chemistry. ,vol. 268, pp. 10425- 10432 ,(1993) , 10.1016/S0021-9258(18)82217-7
Andrea Schroll, Kathrin Eller, Clemens Feistritzer, Manfred Nairz, Thomas Sonnweber, Patrizia A. Moser, Alexander R. Rosenkranz, Igor Theurl, Guenter Weiss, Lipocalin-2 ameliorates granulocyte functionality European Journal of Immunology. ,vol. 42, pp. 3346- 3357 ,(2012) , 10.1002/EJI.201142351
J Forsblad, Anders Gottsäter, Lennart Jacobsson, K Persson, Folke Lindgärde, Clinical manifestations of atherosclerosis in an elderly population are related to plasma neopterin, NGAL and endothelin-1, but not to Chlamydia pneumoniae serology. International Angiology. ,vol. 21, pp. 173- 179 ,(2002)