Clinical manifestations of atherosclerosis in an elderly population are related to plasma neopterin, NGAL and endothelin-1, but not to Chlamydia pneumoniae serology.

摘要: BACKGROUND: Inflammatory mediators secreted by leukocytes are implicated in atherogenesis. Chlamydia (C.) pneumoniae infection has been suggested as a trigger of this process. We investigated relationships between C. Pneumoniae serology, inflammatory and symptomatic cardiovascular disease old age. METHODS: In cross-sectional study at baseline with prospective 4 year follow-up, intraplatelet cyclic 3'-5'adenosine monophosphate (cAMP) 3'-5'guanosine (cGMP), plasma neutrophil gelatinase associated lipocalin (NGAL), soluble tumor necrosis factor receptor-1 (TNFR-1) neopterin endothelin-1 (ET-1) were analysed together IgG IgA antibodies for an elderly reference population (n=140, median age 71 years, females). Twenty-one subjects had clinical manifestations another 21 diagnosed during follow-up. RESULTS: adjusted logistic regression, showed higher levels (p=0.02), NGAL (p=0.04), ET-1 (p<0.01). If excluded from the analysis, (p=0.01) lower serum HDL cholesterol (p=0.03) predicted The presence or against was not disease. Neither there any associations endothelial parameters serology. CONCLUSIONS: derived vasoconstrictive increased Increased No found serology (Less)