Are elevated serum levels of IGFBP-2 after intensive chemotherapy of childhood acute lymphoblastic leukemia a risk factor of relapse?
作者： Krawczuk-Rybak M , Kitszel A
DOI:
关键词: Immunology 、 Disease 、 Gastroenterology 、 Childhood Acute Lymphoblastic Leukemia 、 Pathogenesis 、 Internal medicine 、 Elevated serum 、 Hemoglobin 、 Medicine 、 Intensive chemotherapy 、 Stage (cooking) 、 Risk factor
摘要: INTRODUCTION In the study we investigated association between IGFs, their binding proteins and pathogenesis as well prognostic factors of relapse childhood ALL. MATERIAL AND METHODS 43 children suffering from ALL, observed 7 cases relapse. We studied serum levels IGF-I, IGF-II, IGFBP-3 IGFBP-2 (expressed in SDS) a subgroup with (A) without (B) at diagnosis (1), after induction remission (2) intensive chemotherapy (3). All comparisons were made age-and sex-matched controls. RESULTS It was found that A, values remained high each stage investigation: 3.92 +/- 2.50 (1) 3.68 0.99 3.52 1.26 (3), whereas B they underwent significant reduction 3.87 1.86 3.45 1.25 2.15 1.84 p = 0.02. comparison to control group, correlations IGF-I IGFBP-3, IGF-1 disturbed for whole group investigation. However, obserwed negative correlation hemoglobin (r -0.57 0.0001). CONCLUSION Increased who subsequently disease, suggest might constitute prognosis factor. this requires verification larger children. The further involvement protein process leukemogenesis
scienceopen.com
advms.pl 参考文章(28)
A G Renehan, J Jones, C S Potten, S M Shalet, S T O'Dwyer, Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer British Journal of Cancer. ,vol. 83, pp. 1344- 1350 ,(2000) , 10.1054/BJOC.2000.1462
Eun-Ju Lee, Cristian Mircean, Ilya Shmulevich, Huamin Wang, Jinsong Liu, Antti Niemistö, John J Kavanagh, Je-Ho Lee, Wei Zhang, Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion. Molecular Cancer. ,vol. 4, pp. 7- 7 ,(2005) , 10.1186/1476-4598-4-7
Eleni Petridou, Alkistis Skalkidou, Nick Dessypris, Maria Moustaki, Christos Mantzoros, Evagelos Spanos, Dimitrios Trichopoulos, Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia. Oncology. ,vol. 60, pp. 252- 257 ,(2001) , 10.1159/000055326
H.-S. Kim, S. R. Nagalla, Y. Oh, E. Wilson, C. T. Roberts, R. G. Rosenfeld, Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 12981- 12986 ,(1997) , 10.1073/PNAS.94.24.12981
Stergios J Moschos, Christos S Mantzoros, None, The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology. ,vol. 63, pp. 317- 332 ,(2002) , 10.1159/000066230
Runhua Shi, Herbert Yu, Jerry McLarty, Jonathan Glass, IGF-I and breast cancer: a meta-analysis. International Journal of Cancer. ,vol. 111, pp. 418- 423 ,(2004) , 10.1002/IJC.20233
Peter Vorwerk, Klaus Mohnike, Heike Wex, Friedrich-Wilhelm Röhl, Martin Zimmermann, Werner F. Blum, Uwe Mittler, Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk. The Journal of Clinical Endocrinology and Metabolism. ,vol. 90, pp. 3022- 3027 ,(2005) , 10.1210/JC.2004-0461
David R. Clemmons, Role of insulin-like growth factor binding proteins in controlling IGF actions Molecular and Cellular Endocrinology. ,vol. 140, pp. 19- 24 ,(1998) , 10.1016/S0303-7207(98)00024-0
Klaus Mohnike, Ute Kluba, Werner Blum, Volker Aumann, Peter Vorwerk, Uwe Mittler, [Serum concentrations of insulin-like growth factors (IGF)-I and IGF-II and IGF binding proteins (IGFBP)-2 and IGFBP-3 in 49 children with ALL, NHL or solid tumors]. Klinische Padiatrie. ,vol. 207, pp. 225- 229 ,(1995) , 10.1055/S-2008-1046545
Hideaki Miyake, Isao Hara, Kazuki Yamanaka, Mototsugu Muramaki, Hiroshi Eto, Prognostic significance of insulin-like growth factor (IGF) binding protein-2 to IGF-binding protein-3 ratio in patients undergoing radical cystectomy for invasive transitional cell carcinoma of the bladder. BJUI. ,vol. 95, pp. 987- 991 ,(2005) , 10.1111/J.1464-410X.2005.05453.X