Comparative incidence patterns and trends of gonadal and extragonadal germ cell tumors in England, 1979 to 2003

摘要: BACKGROUND: It is believed that gonadal and extragonadal germ cell tumors (GCTs) arise from primordial cells may have similar etiopathogenesis. Unlike testicular GCTs, there has been limited comprehensive population-based analysis of ovarian GCTs. METHODS: All malignant GCTs all central nervous system (CNS) with benign uncertain behavior were registered in England the age group 0 to 84 years 1979 2003 included current study. Incidence rates calculated adjusted world standard population. RESULTS: There 33,364 (92.5% testes, 3.9% ovary, 3.2% extragonadal) individuals aged years. The CNS was most common site. An initial peak incidence at ages 4 nongerminomas observed sites except ovary. Second peaks between 10 39 more marked among males also sites. these varied by site 14 (CNS), 15 19 (ovary), 25 29 (other sites), 30 34 (testes). A statistically significant increase over time germinomas (testes, CNS) ovary). CONCLUSIONS: The age-incidence patterns suggested a initiation embryonic/fetal life variable tumor progression as result subsequent events be specific. authors concluded future genetic studies should consider enable better understanding their etiology. Cancer 2012. © 2012 American Society.