Gestational Effects of Corticosteroids and Surfactant in Ventilated Rabbits

摘要: ABSTRACT: Maternal corticosteroid treatments decreased lung protein leaks and increased the compliance responses to exogenous surfactant in 27-day preterm rabbits. We asked if maternal at different gestational ages might alter these responses. Pregnant does were given 0.1 mg/kg betamethasone 48 24 h before study of rabbits 27, 28, 29 days age term newborns 31 age. Alternate each gestation treated with 50 after delivery. Alveolar saturated phosphatidylcholine pool sizes similarly control corticosteroid-treated groups. Corticosteroids improved relative values animals not response treatment 27 28 leak radiolabeled albumin lungs alveolar washes all gestations a maximum decrease 16% value gestation. Surfactant this more effectively than did corticosteroids earlier gestations. There potentially beneficial effects either alone or together studied. No noted newborns.