Enhancement of UV-induced skin carcinogenesis by azathioprine: role of photochemical sensitisation.
作者： GRAHAM E. KELLY , WILLIAM D. MEIKLE , DOUGLAS E. MOORE
DOI: 10.1111/J.1751-1097.1989.TB04078.X
关键词: Pharmacology 、 Azathioprine 、 Hairless 、 Phototoxicity 、 Skin tumours 、 Metronidazole 、 Chlorpromazine 、 Carcinogenesis 、 Pharmacotherapy 、 Chemistry
摘要: The phototoxicity of various drugs (chlorpromazine (CPZ), metronidazole (MET), 8-methoxypsoralen (8-MOP), azathioprine (AZA) and the metabolites, 6-mercaptopurine (6-MP), methylnitrothio-imidazole (MNTI), methylnitroimidazole (MNI)) was determined in hairless (Skh-hrl) mice exposed to a light source with broad emission (290–700 nm). Chlorpromazine, MET, 8-MOP, AZA, MNI 6-MP were phototoxic, as by oedematous response skin, at doses comparable those used clinically. The effects long-term drug therapy UV radiation on skin carcinogenesis then determined. Chlorpromazine lesser extent MNTI 6-MP, enhanced photocarcinogen-esis. In each case, both tumour yield proportion malignant:benign tumours increased. results this study imply that prolonged treatment low-level phototoxins predisposes photocarcinogenesis.
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