Diabetische Herzinsuffizienz
作者： Michael Resl , Martin Hülsmann , Richard Pacher , Martin Clodi
DOI: 10.1007/S10354-009-0645-0
关键词: Heart failure 、 Diabetic cardiomyopathy 、 Hyperlipidemia 、 Homeostasis 、 Medicine 、 Diabetes mellitus 、 Subgroup analysis 、 Coronary artery disease 、 Internal medicine 、 Renin–angiotensin system 、 Cardiology 、 General Medicine
摘要: Interactions of glucose metabolism and chronic heart failure have been confirmed by many epidemiologic studies. The association HbA1c with an increasing risk clearly underlines the connection between both diseases. Coronary artery disease (CAD), hypertension diabetic cardiomyopathy are long-term complications diabetes mellitus, resulting in failure. Dysfunction regulation systems leads to specific cardiomyopathy, which has firstly described Rubler. A reduction cardiac expression Na-Ca exchanger pump SERCA2a protein results imbalance calcium handling. overactive renin angiotensin aldosteron system (RAAS) also contributes impairment myocardial function. Hyperlipidaemia, hpyerinsulinaemia hyperglycaemia directly trigger cardiomyopathy. Generally is a clinical diagnosis verified blood tests like NT-proBNP ultrasound. Recommendations on treatment based subgroup analysis large trials.
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