MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer
作者： Lingling Guo , Yongsheng Zhang , Lifeng Zhang , Fengbo Huang , Jinfan Li
DOI: 10.1007/S13277-015-4374-2
关键词: Cancer research 、 Tumor microenvironment 、 Immunology 、 Biology 、 Transforming growth factor beta 、 Cancer 、 Cancer cell 、 Proinflammatory cytokine 、 microRNA 、 Metastasis 、 Signal transduction
摘要: Inflammatory cells and mediators form a major part of the tumor microenvironment play important roles in regulation cancer initiation, cell proliferation, metastasis. MicroRNAs (miRNAs) several physiological pathological processes, including inflammatory cancer. Transforming growth factor-β (TGF-β) is an inflammation-related cytokine that functions both suppression promotion; however, its underlying molecular mechanisms remain unclear. Recent evidence indicates association between miRNAs TGF-β signaling, providing new insight into nature The present review overview interaction cytokines, with emphasis on cross talk signaling their influence behavior. emerging cancer-related inflammation potential to target miRNA pathways for therapy are also discussed.
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