Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex.
作者： Elisabeth Rounis , Lucy Lee , Hartwig R Siebner , James B Rowe , Karl J Friston
DOI: 10.1016/J.NEUROIMAGE.2005.01.037
关键词: Functional imaging 、 Cerebral blood flow 、 Primary motor cortex 、 Stimulation 、 Neuroscience 、 Psychology 、 Neuroplasticity 、 Premotor cortex 、 Transcranial magnetic stimulation 、 Motor system
摘要: Repetitive transcranial magnetic stimulation (rTMS) to the human primary motor cortex (M1) causes bidirectional changes in corticospinal excitability depending on frequency used. We used functional brain imaging compare effects of 5 Hz and 1 Hz-rTMS local inter-regional connectivity within system. Regional cerebral blood flow (rCBF) was measured as a marker synaptic activity at rest during freely selected finger movements. hypothesized that increased cortical induced by over M1 has an opposite effect network from decreased Hz-rTMS. rTMS both frequencies similar rCBF site areas engaged task. The two showed different movement-related coupling between areas. Connectivity analyses also indicated differential connectivity, suggesting role for inferomedial portion left dorsal premotor maintaining performance. These results suggest rapid reorganization system occurs maintain task performance periods altered excitability. This differs according modulation which is function frequency. study extends work Lee et al. (Lee, L., Siebner, H.R., Rowe, J.B., Rizzo, V. Rothwell, J.C. Frackowiak, R.S. Friston, K.J., 2003. Acute remapping low-frequency repetitive stimulation. J. Neurosci. 23, 5308-5318.) providing evidence pattern acute following depends direction conditioning.
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