Genomic Instability in Pituitary Adenomas

摘要: Pituitary adenomas most commonly are identified as small, incidental microadenomas. They however may progress to macroadenoma forming intra and later suprasellar tumors which in about 1/3 of cases invade surrounding structures at the time diagnosis. Mechanism pituitary tumorigenesis remains still elusive. Because value karyotyping is limited by technical problems related cytogenetic methods, we studied spectrum chromosomal imbalances associated with adenoma using comparative genomic hybridization (CGH). Copy number aberrations on all 22 autosomes were evaluated CGH advanced computer software. In total, fifteen patients included study 9 non-invasive, 4 invasive two recurrent adenomas. The mean age 48 years ranging from 36 68 years. Five showed hormonal activity. histogram 15 representing DNA an incidence curve along each chromosome losses particularly for chromosomes 1p, 2q, 4, 5, 6, 11q, 12q, 13q 18q well overrepresentation 9q, 16p, 17p, 19, 20q. Functioning carried more than non-functioning, specifically deletions overrepresentations 17 19. Invasive 1p34 non-invasive tumors. Recurrent harbored alterations primary tumors, gains. data accessible our online tumor database http://amba.charite.de/cgh. Reviewing existing literature genetics discussing results this context, hope that will contribute knowledge neoplasm.