Chondroitin sulfate expression predicts poor outcome in breast cancer.

摘要: Experimental studies have established that the sulfated glycosaminoglycans heparan sulfate and chondroitin act as co-receptors of cytokines growth factors drive malignant cell phenotype remodelling surrounding tumor stroma. However, clinical relevance these remains ill-defined. The present study investigates significance expression in cells stroma, respectively, tumors from two independent cohorts breast cancer patients (cohort I: 144 patients, 130 evaluable samples; cohort II: 498 469 ER-positive ~86% both cohorts). Kaplan-Meier analysis Cox proportional hazards modelling were used to assess relationship between recurrence-free overall survival. High was shown predict shorter survival (P=0.007, I; P=0.024, II) P=0.044; P<0.001) cohorts. In multivariate analysis, high be an independent, predictive factor poor hazard ratio 2.28: 95% confidence interval 1.08-4.81, P=0.031; 1.71: 1.23-2.38, P=0.001). stroma showed no correlation with known markers aggressiveness or outcome either cohort. Our data suggest is associated adverse primary cancer, supporting idea a functional potentially targetable role disease. (Less)