C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
作者： E Kurzejamska , J Johansson , K Jirström , V Prakash , S Ananthaseshan
关键词:
摘要: CCAAT-enhancer binding protein β (C/EBPβ) is a transcription factor that has critical role in mammary gland development and breast cancer progression. Loss of C/EBPβ increases metastatic dissemination mouse tumor cells. However, the mechanism by which expression affects metastasis formation remains unknown. This study aims at determining relationship between survival patients, elucidating C/EBPβ's link with formation. was evaluated 137 cases human cancer, correlation overall estimated Kaplan–Meier analysis. Additionally, 4T1 model used for vivo studies. Decreased found to be associated shorter patients. In murine model, loss growth, morphology promotes spread lungs. Immunohistochemical analyses showed inhibition leads increased major histocompatibility complex II (MHCII) expression, followed accumulation CD45-, CD3- CD4-positive (CD4+) lymphocytes tumors. Inflammation involvement C/EBPβ-mediated confirmed DNA microarray experiments on CD4+ cell-deprived nude mice. anti-CD3 anti-CD4 treatments C/EBPβ-silenced tumor-bearing mice resulted reverting effect growth metastasis. Altogether, predictor lung model. The involves immunologic response depending activation MHCII tumor.
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