Protection of bile ducts in liver transplantation: looking beyond ischemia.

摘要: Biliary complications, especially nonanastomotic biliary strictures (NAS), are a major cause of morbidity after orthotopic liver transplantation. Of all donor and recipient characteristics known to increase the risk developing NAS, role prolonged ischemia times is most extensively described in literature. However, there increasing evidence that several other, non-ischemia-related factors play critical pathogenesis NAS as well. The clinical presentation may vary considerably among transplant recipients, including large variations time occurrence, location severity strictures. Additional underlying causes such bile salt toxicity immune-mediated injury believed explain wide spectrum Current emerging insight potential targets reduce preserve ducts discussed this overview.