Polyamide Backbone Modified Cell Targeting and Penetrating Peptides in Cancer Detection and Treatment.
作者： Sunil S. Shah , Nelson Casanova , Gina Antuono , David Sabatino
关键词: Cancer detection 、 First generation 、 Peptide sequence 、 Cell targeting 、 Peptide 、 Polyamide 、 Chemistry 、 Computational biology 、 Cancer treatment 、 Peptidomimetic
摘要: Cell penetrating and targeting peptides (CPPs CTPs) encompass an important class of biochemically active owning the capabilities translocating within selected cell types. As such, they have been widely used in delivery imaging therapeutic agents for diagnosis treatment various diseases, especially cancer. Despite their potential utility, first generation CTPs CPPs based on native peptide sequences are limited by poor biological pharmacological properties, thereby restricting efficacy. Therefore, medicinal chemistry approaches designed developed to construct related peptidomimetics. Of specific interest herein, design applications which modify polyamide backbone lead CPPs. These modifications aim improve biochemical characteristics sequence order enhance its diagnostic capabilities. This review will focus a set peptidomimetics whose has modified cancer detection treatment.
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Md. Rowshon Alam, Xin Ming, Michael Fisher, Jeremy G. Lackey, Kallanthottathil G. Rajeev, Muthiah Manoharan, Rudy L. Juliano, Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA Bioconjugate Chemistry. ,vol. 22, pp. 1673- 1681 ,(2011) , 10.1021/BC200235Q
Zheng-Hong Peng, Jindřich Kopeček, Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer Journal of the American Chemical Society. ,vol. 137, pp. 6726- 6729 ,(2015) , 10.1021/JACS.5B00922
Xue Li, Zuoxu Xie, Cao Xie, Weiyue Lu, Chunli Gao, Henglei Ren, Man Ying, Xiaoli Wei, Jie Gao, Bingxia Su, Yachao Ren, Min Liu, D-SP5 Peptide-Modified Highly Branched Polyethylenimine for Gene Therapy of Gastric Adenocarcinoma. Bioconjugate Chemistry. ,vol. 26, pp. 1494- 1503 ,(2015) , 10.1021/ACS.BIOCONJCHEM.5B00137
Caroline Proulx, Stan Yoo, Michael D. Connolly, Ronald N. Zuckermann, Accelerated Submonomer Solid-Phase Synthesis of Peptoids Incorporating Multiple Substituted N-Aryl Glycine Monomers. Journal of Organic Chemistry. ,vol. 80, pp. 10490- 10497 ,(2015) , 10.1021/ACS.JOC.5B01449
Patrick T. Caswell, Jim C. Norman, Integrin trafficking and the control of cell migration. Traffic. ,vol. 7, pp. 14- 21 ,(2006) , 10.1111/J.1600-0854.2005.00362.X
Stesha C. Joseph, Brittany A. Blackman, Megan L. Kelly, Mariana Phillips, Michael W. Beaury, Ivonne Martinez, Christopher J. Parronchi, Constantine Bitsaktsis, Allan D. Blake, David Sabatino, Synthesis, characterization, and biological activity of poly(arginine)‐derived cancer‐targeting peptides in HepG2 liver cancer cells Journal of Peptide Science. ,vol. 20, pp. 736- 745 ,(2014) , 10.1002/PSC.2665
Siegmund Reissmann, Cell penetration: scope and limitations by the application of cell‐penetrating peptides Journal of Peptide Science. ,vol. 20, pp. 760- 784 ,(2014) , 10.1002/PSC.2672
Yunpeng Ye, Sharon Bloch, Baogang Xu, Samuel Achilefu, Design, Synthesis, and Evaluation of Near Infrared Fluorescent Multimeric RGD Peptides for Targeting Tumors Journal of Medicinal Chemistry. ,vol. 49, pp. 2268- 2275 ,(2006) , 10.1021/JM050947H
Ying Liu, Sebastian C. J. Steiniger, YoungSoo Kim, Gunnar F. Kaufmann, Brunhilde Felding-Habermann, Kim D. Janda, Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery. Molecular Pharmaceutics. ,vol. 4, pp. 435- 447 ,(2007) , 10.1021/MP060122J
Amir Nasrolahi Shirazi, Karissa L Paquin, Niall G Howlett, Dindyal Mandal, Keykavous Parang, None, Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery. Molecules. ,vol. 19, pp. 13319- 13331 ,(2014) , 10.3390/MOLECULES190913319