Recent Advances and Future Challenges in Glycan Microarray Technology

摘要: Glycan microarrays, carrying hundreds of different sugars on chip surfaces, have become a standard tool for the study interactions biomolecules with carbohydrates. The chip-based format offers important advantages, including ability to screen in parallel several thousand binding events single slide, minimal amount sample required one experiment, and multivalent display that mimics presentation carbohydrates nature. This chapter presents recent advances future challenges glycan microarray technology. We describe immobilization detection methods as well applications glycomics, drug discovery, biomedicine.