Genes involved in cerebrospinal fluid production as candidate genes for late-onset Alzheimer's disease: a hypothesis.

摘要: In rare patients with autosomal dominant, early-onset Alzheimer's disease (AD), pathogenic mutations in the genes encoding β-amyloid precursor protein, and γ-secretase-complex components presenilin-1 presenilin-2 appear to result (Aβ) overproduction. The pathological accumulation of Aβ far more common late-onset AD is likely be deficient clearance Aβ. There evidence that production turnover cerebrospinal fluid (CSF) help clear toxic molecules such as from interstitial space brain bloodstream. CSF have been shown decreased aging conditions, normal pressure hydrocephalus AD. Reduced formation CSF, diminished Aβ, may play an important role onset progression If reduced a risk factor for AD, then its incidence ought increased under conditions circulatory failure. this paper, authors hypothesize variations involved absorption contribute pathogenesis