What Is The “Safest” Non-Steroidal Anti-Inflammatory Drugs?
作者： Hassan
DOI: 10.3844/AMJSP.2012.115.123
关键词: Internal medicine 、 Naproxen 、 Ibuprofen 、 Safety profile 、 Adverse effect 、 Pharmacology 、 COX-2 inhibitor 、 Celecoxib 、 Adverse drug reaction 、 Nephrotoxicity 、 Medicine
摘要: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) which are widely used in clinical practice also very well-known for their various adverse reactions. Each NSAID has its own unique safety profile and selecting an appropriate m ust be individualized each patient based on his or her medical needs risk factors. We reviewed literatures NSAIDs, focusing reaction profile. compared the inci dence of from individual NSAIDs according to organ systems. This review includes both selective COX-2 inhibitors non- NSAIDs. Based most up-to-date evidence, ibuprofen appears preferred favorable GI nephrotoxicity profiles. Naproxen might considered patients who have greater cardiac risk. Celecoxib, at do se less than equal 200 mg day -1 , option high bleeding. Key word: (NSAIDs), inhibitor, drug reaction, reactions, profile, clinic al practice, systems
thescipub.com
researchgate.net 参考文章(60)
F. C. Luft, J. F. E. Mann, M. Goerig, K. Brune, Ibuprofen as an over-the-counter drug: is there a risk for renal injury? Clinical Nephrology. ,vol. 39, pp. 1- 6 ,(1993)
Gregory V. Warren, Stephen M. Korbet, Melvin M. Schwartz, Edmund J. Lewis, Minimal change glomerulopathy associated with nonsteroidal antiinflammatory drugs. American Journal of Kidney Diseases. ,vol. 13, pp. 127- 130 ,(1989) , 10.1016/S0272-6386(89)80130-1
Carlo Patrono, Michael J. Dunn, The clinical significance of inhibition of renal prostaglandin synthesis Kidney International. ,vol. 32, pp. 1- 12 ,(1987) , 10.1038/KI.1987.164
Gurkirpal Singh, John G Fort, Jay L Goldstein, Roger A Levy, Patrick S Hanrahan, Alfonso E Bello, Lilia Andrade-Ortega, Carl Wallemark, Naurang M Agrawal, Glenn M Eisen, William F Stenson, George Triadafilopoulos, SUCCESS-I Investigators, Celecoxib Versus Naproxen and Diclofenac in Osteoarthritis Patients: SUCCESS-I Study The American Journal of Medicine. ,vol. 119, pp. 255- 266 ,(2006) , 10.1016/J.AMJMED.2005.09.054
Frank Andersohn, René Schade, Samy Suissa, Edeltraut Garbe, Cyclooxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs and the Risk of Ischemic Stroke Stroke. ,vol. 37, pp. 1725- 1730 ,(2006) , 10.1161/01.STR.0000226642.55207.94
David M. Clive, Jeffrey S. Stoff, Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs New England Journal of Medicine. ,vol. 310, pp. 563- 572 ,(1984) , 10.1056/NEJM198403013100905
Lois La Grenade, Lauren Lee, Joyce Weaver, Renan Bonnel, Claudia Karwoski, Laura Governale, Allen Brinker, Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors. Drug Safety. ,vol. 28, pp. 917- 924 ,(2005) , 10.2165/00002018-200528100-00008
Christianne L. Roumie, Edward F. Mitchel, Lisa Kaltenbach, Patrick G. Arbogast, Patricia Gideon, Marie R. Griffin, Nonaspirin NSAIDs, Cyclooxygenase 2 Inhibitors, and the Risk for Stroke Stroke. ,vol. 39, pp. 2037- 2045 ,(2008) , 10.1161/STROKEAHA.107.508549
Anthony G Johnson, Tuan V Nguyen, Richard O Day, Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis Annals of Internal Medicine. ,vol. 121, pp. 289- 300 ,(1994) , 10.7326/0003-4819-121-4-199408150-00011
Frank L Lanza, , Francis K L Chan, Eamonn M M Quigley, Guidelines for prevention of NSAID-related ulcer complications The American Journal of Gastroenterology. ,vol. 104, pp. 728- 738 ,(2009) , 10.1038/AJG.2009.115