Exosomes Secreted from Human Cancer Cell Lines Contain Inhibitors of Apoptosis (IAP)

摘要: Exosomes are endosomal-derived nanovesicles released by normal and tumor cells which have been shown to transfer functionally active protein, lipids, mRNAs miRNAs between cells. Varying in molecular profiles, biological roles, functional roles protein contents, exosomes described as “multi-purpose carriers” playing a role supporting the survival growth of The IAP Survivin has found be present exosomes. However, existence other IAPs is still unknown. Survivin, cIAP1, cIAP2 XIAP mRNA differently expressed panel cell lines: DLCL2, HeLa, MCF-7, Panc-1, PC3. were isolated from conditioned media collected RNA extracted. Our results provide evidence that like XIAP, cIAP1 proteins expression, however, differentially across lines. presence these bioactive molecules may not only serve warning signals, but also play providing protection cancer against changes constantly occurring microenvironment.