Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.
作者： Nadeem Riaz , Luc G. Morris , William Lee , Timothy A. Chan
DOI: 10.1016/J.GENDIS.2014.07.002
关键词: Genomics 、 Chromatin 、 Genome 、 Biology 、 Head and neck cancer 、 Gene 、 Notch signaling pathway 、 Cell 、 Molecular genetics 、 Bioinformatics
摘要: The past decade has seen an unprecedented increase in our understanding of the biology and etiology head neck squamous cell carcinomas (HNSCC). Genome-wide sequencing projects have identified a number recurrently mutated genes, including unexpected alterations NOTCH pathway chromatin related genes. Gene-expression profiling 4 distinct genetic subtypes which show some parallels to lung carcinoma biology. identification human papilloma virus as one causative agent subset oropharyngeal cancers their association with favorable prognosis opened up avenues for new therapeutic strategies. expanding knowledge underlying molecular abnormalities this once very poorly understood cancer should allow increasingly rational clinical trial design improved patient outcomes.
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