Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

摘要: Abstract In order to define more clearly the role of chromosome 9 loss in head and neck squamous cell carcinoma (HNSCC), 29 invasive carcinomas 17 preinvasive lesions were analyzed for heterozygosity (LOH) on 9. We found LOH 21 (72%) HNSCC tumors using highly polymorphic microsatellite markers. 21, was at all informative sites p arm with no q arm. Further mapping tumors, partial 9p arm, localized a common region between markers D9S165 D9S156 . Deletion this has been several other tumor types implying presence suppressor gene locus. The inactivation may represent most commonly described genetic alteration HNSCC. A similar incidence allelic identified 12 (71%) lesions. identical frequency suggests that is an early event progression.