Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer

摘要: Head and neck cancer, while relatively uncommon in the United States remains a prevalent condition throughout world potentially has substantial quality of life issues for these patients. As disease classification, head represents diverse population cancers which are linked anatomically, extending from clavicles to skull base. There many histologic types cancer within this grouping, although vast majority squamous cell carcinomas. The most significant sites oral cavity, oropharynx, larynx hypopharynx, other sites, such as sinuses, much less common more heterogeneous. Treatment consists surgery, radiation therapy chemotherapy, alone or combination. decision use particular therapeutic regimen been related TNM stage, primary site, comorbidity patient. More recently, molecular studies global gene expression, methylation status, microRNA proteomic changes, continue identify important alterations genetic make-up tumors, all will be expanded upon chapter.