Plasmacytoid Dendritic Cells in HIV Infection
作者： Meagan O’Brien , Olivier Manches , Nina Bhardwaj
DOI: 10.1007/978-1-4614-4433-6_3
关键词: Immunology 、 Innate immune system 、 Immune system 、 Biology 、 Signal transduction 、 Major histocompatibility complex 、 Pathogenesis 、 Immunosuppression 、 Progenitor cell 、 Regulatory T cell
摘要: Plasmacytoid dendritic cells (pDCs) are innate immune that specialized to produce interferon-alpha (IFNα) and participate in activating adaptive responses. Although IFNα inhibits HIV-1 (HIV) replication vitro, pDCs may act as inflammatory immunosuppressive (DCs) rather than classical antigen-presenting during chronic HIV infection vivo, contributing more pathogenesis protection. Improved understanding of HIV–pDC interactions yield potential new avenues discovery prevent transmission, blunt activation exhaustion, enhance beneficial In this chapter we discuss pDC biology, including development from progenitors, trafficking localization the body, signaling pathways involved activation. We focus on role disease progression activation, immunosuppression through regulatory T cell development. Lastly, future directions for field which needed strengthen our current transmission pathogenesis.
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