Persistent Decreases in Blood Plasmacytoid Dendritic Cell Number and Function Despite Effective Highly Active Antiretroviral Therapy and Increased Blood Myeloid Dendritic Cells in HIV-Infected Individuals
作者： Jihed Chehimi , Donald E. Campbell , Livio Azzoni , Darlene Bacheller , Emmanouil Papasavvas
DOI: 10.4049/JIMMUNOL.168.9.4796
关键词:
摘要: Dendritic cells (DC) have an instrumental role in the activation and function of both innate adaptive immune responses. In humans, at least two distinct DC subsets been characterized based on phenotypic markers: myeloid (MDC) plasmacytoid (PDC). Both are critical producers cytokines (IL-12 for MDC type I/II IFNs PDC) functionally different. We show this study that HIV(+) individuals a significant decrease number Lin(-)HLA-DR(+)CD123(+) BDCA-2(+) PDC compared with uninfected donors (p = 0.0001). also sustained impairment viral-induced IFN-alpha production 5000 HIV-1 copies/ml. The inverse association viral load number, but not secretion or PDC, suggests control. Our data suggest differentially reconstituted during recovery associated antiviral therapy. persistent certain may result defect DC-mediated functions despite effective treatment regimen.
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