Allergen-induced Asthmatic Responses: Relationship Between Increases in Airway Responsiveness and Increases in Circulating Eosinophils, Basophils, and Their Progenitors
作者： Peter G. Gibson , Patrick J. Manning , Paul M. O'byrne , Adele Girgis-Gabardo , Jerry Dolovich
关键词: Provocation test 、 Asthma 、 Inhalation 、 Allergy 、 Medicine 、 Immunology 、 Histamine 、 Allergen 、 Basophil 、 Eosinophil 、 Pulmonary and Respiratory Medicine
摘要: The inflammatory response during allergen-induced asthma was assessed using serial measures of peripheral blood eosinophils (Eo), basophils (B), and Eo/B progenitor cells (Eo/B- CFU). A group 14 stable asthmatic individuals (β2-agonists only as needed) had inhalation provocation tests with allergen (18 in total) diluent. Serial samples were taken before 1 24 h after the tests; methylcellulose cultures for Eo/B-CFU granulocyte-macrophage (GM-CFU) scored at days. Circulating Eo, B, increased when this resulted histamine airway responsiveness (n = 13). In 5 subjects isolated early responses counts did not change. There no change GM-CFU allergen. ratio circulating Eo/B- CFU negatively correlated baseline (r -0.8, p < 0.05). Four who an ch...
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