Potential Health Benefits of Dietary Phytoestrogens: A Review of the Clinical, Epidemiological, and Mechanistic Evidence1

作者: Doris M. Tham , Christopher D. Gardner , William L. Haskell

DOI: 10.1210/JCEM.83.7.4752

关键词: EndocrinologyLignanBiologyIsoflavonesInternal medicineOsteoporosisClinical trialEpidemiologyPhytoestrogensAnimal studiesPopulation

摘要: Phytoestrogens represent a family of plant compounds that have been shown to both estrogenic and antiestrogenic properties. A variety these their mammalian metabolic products identified in various human body fluids fall under two main categories: isoflavones lignans. wide range commonly consumed foods contain appreciable amounts different phytoestrogens. For example, soy flax are particularly good sources lignans, respectively. Accumulating evidence from molecular cellular biology experiments, animal studies, and, limited extent, clinical trials suggests phytoestrogens may potentially confer health benefits related cardiovascular diseases, cancer, osteoporosis, menopausal symptoms. These potential consistent with the epidemiological rates heart disease, cancers, osteoporotic fractures, symptoms more favorable among population...

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