Close Relationship of the Major Excreted Protein of Transformed Murine Fibroblasts to Thiol-dependent Cathepsins
作者： David T. Denhardt , Craig L. J. Parfett , Marit Nilsen-Hamilton , Dylan R. Edwards , Richard T. Hamilton
DOI:
关键词: Peptide sequence 、 Cathepsin H 、 Cysteine 、 Cathepsin 、 Proteases 、 Messenger RNA 、 Biochemistry 、 Biology 、 Molecular biology 、 Enzyme 、 Complementary DNA
摘要: Complementary DNA clones corresponding to 638 nucleotides of the messenger RNA encoding major portion murine excreted protein have been isolated and sequenced. The amino acid sequence a part deduced from reveals substantial significant homology with cysteine proteases actinidin, rat cathepsin H, papain. Since amount secreted by cultured cells is often enhanced transformation, it implicated in oncogenic phenomena may play role metastatic process virtue its proteolytic activity.
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