Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
作者： D. R. Edwards , G. Murphy , J. J. Reynolds , S. E. Whitham , A. J. Docherty
DOI: 10.1002/J.1460-2075.1987.TB02449.X
关键词:
摘要: Exposure of quiescent MRC-5 human fibroblasts to growth factors such as epidermal factor, basic fibroblast factor or embryonal carcinoma-derived resulted in the induction mRNA transcripts encoding metalloproteinases collagenase and stromelysin specific metalloproteinase inhibitor TIMP, whilst expression collagen fibronectin was relatively unaffected. cells presence transforming beta (TGF-beta) inhibition a synergistic increase TIMP expression. TGF-beta alone did not significantly induce These effects on were reflected increased secretion protein activity. Nuclear run-off analysis factor-induced transcription revealed that modulation due transcriptional mechanisms. The observations suggest exerts selective effect extracellular matrix deposition by modulating action other
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