Quantitative MRI of Perivascular Spaces at 3T for Early Diagnosis of Mild Cognitive Impairment

摘要: BACKGROUND AND PURPOSE: The limitations inherent in the current methods of diagnosing mild cognitive impairment have constrained use early therapeutic interventions to delay progression dementia. This study evaluated whether quantifying enlarged perivascular spaces observed on MR imaging can help differentiate those with from cognitively healthy controls and, thus, an application diagnosis impairment. MATERIALS METHODS: We automated identification brain Images using a custom quantitative program designed Matlab. then quantified densities for patients (n = 14) and age-matched 15) compared them determine density serve as surrogate diagnosis. RESULTS: Quantified percentage volume fraction (v/v%), were calculated be 2.82 ± 0.40 v/v% 4.17 0.57 group subcortical (P CONCLUSIONS: was found significantly higher control subjects. spaces, therefore, may useful biomarker