Anticancer Activity of Nanoparticles Based on PLGA and its Co-polymer: In-vitro Evaluation
作者： Motahare-Sadat Hosseini , Issa Amjadi , Mohammad Rabiee
关键词: Fourier transform infrared spectroscopy 、 Nanoparticle 、 Lactide 、 Nuclear chemistry 、 Sonication 、 PLGA 、 Nanotechnology 、 Differential scanning calorimetry 、 Doxorubicin 、 Targeted drug delivery 、 Chemistry
摘要: Attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) and doxorubicin. Biological evaluation physio-chemical characterizations were performed elucidate the effects of initial drug loading polymer composition nanoparticle properties its antitumor activity. PLGA formulated by sonication method. Lactide/glycolide ratio doxorubicin amounts tailored. Fourier transform infrared spectroscopy (FTIR) differential scanning calorimetry (DSC) employed identify presence within nanospheres. The in vitro release studies determine ant net rates over 24 h 20 days, respectively. Furthermore, cytotoxicity assay was measured evaluate therapeutic potency doxorubicin-loaded nanoparticles. Spectroscopy thermal results showed that loaded into particles successfully. It observed lactide/glycolide content containing has more prominent role tuning particle characteristics. Doxorubicin profiles from 75 nanospheres demonstrated cumulative rate increased slightly higher burst detected comparison 50 MTT data revealed induced activity enhanced encapsulation process, increasing glycolide portion. led conclusion controlling hydrophilicity, we can adjust targeting blood clearance, which may play a for application chemotherapy.
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