Preparation and Characterization of Rifampin Loaded Mesoporous Silica Nanoparticles as a Potential System for Pulmonary Drug Delivery
作者： Kambiz Gilani , Seyed Alireza Mortazavi , Meysam Mohseni
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摘要: The goal of this research is to determine the feasibility loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it welldocumented and much used anti tuberculosis drug. nanoparticles were prepared by using tetraethyl ortho silicate cetyltrimethyl ammonium bromide (as surfactant). characterized in terms their particle size measurement porosimetry. results showed that 218 ± 46 nm (mean SD) surface area 816 m 2 g -1 . In order load within mesopores, adsorption experiments three different solvents (methanol, water dimethyl sulfoxide) carried out. procedure resulted significant improvement amount loaded methanol found be suitable solvent, providing drug entrapment efficiency 52 %. underwent invitro tests including, SEM release. in-vitro release investigated buffer phosphate (pH=7.4). Regarding study, biphasic pattern observed. drug-loaded capable releasing 95% content after 24 h, following faster first four hours. seem have potential for use pulmonary delivery.
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