Rhodium-catalyzed asymmetric 1,6-addition of aryltitanates to enynones giving axially chiral allenes.
作者： Tamio Hayashi , Norihito Tokunaga , Kazuya Inoue
DOI: 10.1021/OL036309F
关键词: Enol 、 Silylation 、 Rhodium 、 Medicinal chemistry 、 Organic chemistry 、 Axial symmetry 、 Catalysis 、 Yield (chemistry) 、 Reagent 、 Chemistry
摘要: The addition of aryltitanate reagents ArTi(OPr-i)4Li to 3-alkynyl-2-en-1-ones in the presence chlorotrimethylsilane and a rhodium-(R)-segphos as catalyst proceeded 1,6-fashion give high yield axially chiral allenylalkenyl silyl enol ethers with up 93% ee.
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sci-hub.se 参考文章(30)
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