Minor H Antigens Introduced on H-2 Different Stimulating Cells Cross-React at the Cytotoxic T Cell Level during in Vivo Priming

摘要: The cellular basis of the cross-priming observed with minor histocompatibility antigens on H-2 different cells was investigated. Cytotoxic T induced against alloantigens show absolute restriction at effector level ([ 51 Cr]-release). That is, F 1 (BALB/c × BALB.B) (H-2 d/b ) cytotoxic by immunization B10(H-2 b are not able to lyse B10.D2(H-2 d targets. But an injection B10 does prime mice for a secondary response B10.D2. technique inducing function polyclonally Con A in absence alloantigen used here establish that such reflects what happens cell level. It is shown animal previously injected has expanded pools memory reactive and From this it concluded that: H structures B10.D2 do cross-react during vivo priming, because normal cross-prime whereas tumor not, then precursors probably committed respond antigen bearing either maternal or paternal haplotype before they encounter antigen. Cross-priming may be explained foreign being presented host surface macrophages. Therefore priming restricted type but both types host.