Understanding the mechanism of cure in testicular cancer
作者： Hayden Pearce
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摘要: The expression of cancer testis antigens (CTAgs) is normally restricted to spermatogenic cells the but also present in many cancers including testicular germ cell tumours (TGCTs). CTAg-specific T responses have been identified patients with other solid tumours, and here we TGCT patients. MAGEA-family specific were detected 21/49 a magnitude up 0.149% total peripheral blood mononuclear cells. Responses multiple MAGEA frequently seminoma irrespective tumour stage. Conversely, NSGCTT only developed towards MAGEA3, which strongly associated disease progression. Longitudinal analysis revealed that MAGE-specific immune diminished over time by 95%, correlated removal antigens. CD8 demonstrated cytotoxic potential against endogenously presented antigen. Tumour infiltrating antigen experienced, recently activated, oligoclonal populations; expressed inhibitory molecules, TIM-3 PD-1. Proliferation cytokine secretion was suppressed vivo rescued vitro stimulation, indicative an exhausted phenotype. Our findings significant implications development novel immunotherapy cancer.
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