Chaperoning antigen presentation by MHC class II molecules and their role in oncogenesis.
作者： Marije Marsman , Ingrid Jordens , Alexander Griekspoor , Jacques Neefjes
DOI: 10.1016/S0065-230X(05)93004-2
关键词:
摘要: Tumor vaccine development aimed at stimulating the cellular immune response focuses mainly on MHC class I molecules. This is not surprising since most tumors do express II or CD1 Nevertheless, successful targets for cancer immunotherapy, leukemia and melanoma, often molecules, which leaves no obvious reason to ignore molecules as a mediator in anticancer therapy. We review current state of knowledge process II-restricted antigen presentation subsequently discuss consequences expression tumor surveillance induction an efficient mediated antitumor vivo after vaccination.
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