A Genome-wide SNP Genotyping Array Reveals Patterns of Global and Repeated Species-Pair Divergence in Sticklebacks

摘要: Summary Genes underlying repeated adaptive evolution in natural populations are still largely unknown. Stickleback fish ( Gasterosteus aculeatus ) have undergone a recent dramatic evolutionary radiation, generating numerous examples of marine-freshwater species pairs and small number benthic-limnetic found within single lakes [1]. We developed new genome-wide SNP genotyping array to study patterns genetic variation sticklebacks over wide geographic range, scan the genome for regions that contribute or pairs. Surveying 34 global with 1,159 informative markers revealed substantial variation, predominant reflecting demographic history structure. After correcting structure filtering neutral markers, we detected large shifts allele frequency at some loci, identifying both known novel loci likely contributing divergence. Several fall close genes implicated epithelial barrier immune functions, which changed as adapt contrasting environments. Specific alleles differentiating sympatric shared nearby solitary populations, suggesting an allopatric origin variants selection pressures unrelated sympatry initial formation these classic vertebrate