Low serum levels of DHEAS in untreated polymyalgia rheumatica/giant cell arteritis.

摘要: OBJECTIVE: To address a controversy regarding the existence of relative adrenal hypofunction in patients with untreated polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) we evaluated baseline serum levels ACTH, cortisol, DHEAS cohort recent onset PMR/GCA not previously treated glucocorticoids, comparison healthy controls. Possible correlations between laboratory measures disease activity were also explored. METHODS: Basal these hormones prospectively investigated 25 active compared those age- sex-matched control subjects. RESULTS: Of patients, 19 had isolated PMR 6 biopsy-proven GCA + PMR. cortisol ACTH did differ from subjects; relation to inflammatory status, lower than expected basal production was observed PMR/GCA. Baseline significantly all In significant correlation found values activity. The percentage reduction severity response higher women men. CONCLUSION: Patients new-onset before steroid treatment have inappropriately normal ongoing inflammation, These data support GCA.