Comparative Effectiveness in Esophagogastric Cancer

摘要: Cancer of the esophagus and gastroesophageal junction (GEJ) continues to have a dismal prognosis, with incidence esophageal cancer increasing in United States. Although radical resection was initially primary treatment for this disease process, systemic chemotherapy radiation been shown play role prolonging survival most patient populations. This chapter explores evidence that guides GEJ today. Chemotherapy therapy were introduced as modalities cancers when it became evident surgical alone provided poor long-term rates. A variety strategies explored including preoperative (neoadjuvant) postoperative (adjuvant) chemotherapy, without radiation. The suggests neoadjuvant or chemoradiotherapy provides better outcomes compared surgery esophageal, GEJ, gastric cancers. Studies indicate trend towards improved is alone. When patients undergone node-positive receiving therapy, some form adjuvant recommended. also management extent lymph node dissection. It includes discussion about adherence national guidelines terms examinations.