作者: J.J. Bonenkamp , J. Hermans , M. Sasako , K. Welvaart , I. Songun
DOI: 10.1056/NEJM199903253401202
关键词:
摘要: Background Curative resection is the treatment of choice for gastric cancer, but it unclear whether this operation should include an extended (D2) lymph-node dissection, as recommended by Japanese medical community, or a limited (D1) dissection. We conducted randomized trial in 80 Dutch hospitals which we compared D1 with D2 dissection cancer terms morbidity, postoperative mortality, long-term survival, and cumulative risk relapse after surgery. Methods Between August 1989 July 1993, total 996 patients entered study. Of these patients, 711 (380 group 331 group) underwent randomly assigned curative intent, 285 received palliative treatment. The procedures quality control included instruction supervision operating room monitoring pathological results. Results Patients had significantly higher rate complications than did those (43 percent vs. 2...