Extended Lymph-Node Dissection for Gastric Cancer

作者: J.J. Bonenkamp , J. Hermans , M. Sasako , K. Welvaart , I. Songun

DOI: 10.1056/NEJM199903253401202

关键词:

摘要: Background Curative resection is the treatment of choice for gastric cancer, but it unclear whether this operation should include an extended (D2) lymph-node dissection, as recommended by Japanese medical community, or a limited (D1) dissection. We conducted randomized trial in 80 Dutch hospitals which we compared D1 with D2 dissection cancer terms morbidity, postoperative mortality, long-term survival, and cumulative risk relapse after surgery. Methods Between August 1989 July 1993, total 996 patients entered study. Of these patients, 711 (380 group 331 group) underwent randomly assigned curative intent, 285 received palliative treatment. The procedures quality control included instruction supervision operating room monitoring pathological results. Results Patients had significantly higher rate complications than did those (43 percent vs. 2...

参考文章(19)
J. Benedetti, Norman C. Estes, J. Jacobson, K. Touijer, J. S. Macdonald, Inadequate documentation and resection for gastric cancer in the United States: a preliminary report. American Surgeon. ,vol. 64, pp. 680- 685 ,(1998)
A M Bunt, J Hermans, V T Smit, C J van de Velde, G J Fleuren, J A Bruijn, Surgical/pathologic-stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. Journal of Clinical Oncology. ,vol. 13, pp. 19- 25 ,(1995) , 10.1200/JCO.1995.13.1.19
J P Griffith, H M Sue-Ling, I Martin, M F Dixon, M J McMahon, A T Axon, D Johnston, Preservation of the spleen improves survival after radical surgery for gastric cancer. Gut. ,vol. 36, pp. 684- 690 ,(1995) , 10.1136/GUT.36.5.684
J. J. Bonenkamp, C. J. H. van de Velde, G. H. M. Kampschöer, J. Hermans, P. Hermanek, M. Bemelmans, D. J. Gouma, M. Sasako, K. Maruyama, Comparison of factors influencing the prognosis of Japanese, German, and Dutch gastric cancer patients World Journal of Surgery. ,vol. 17, pp. 410- 414 ,(1993) , 10.1007/BF01658714
Jürgen D. Roder, Knut Böttcher, J. Rüdiger Siewert, Raymonde Busch, Paul Hermanek, Hans-Joachim Meyer, , Prognostic factors in gastric carcinoma. Results of the German gastric carcinoma study 1992 Cancer. ,vol. 72, pp. 2089- 2097 ,(1993) , 10.1002/1097-0142(19931001)72:7<2089::AID-CNCR2820720706>3.0.CO;2-H
J. J. Bonenkamp, I. Songun, J. Hermans, C. J. H. De Van Velde, Prognostic value of positive cytology findings from abdominal washings in patients with gastric cancer British Journal of Surgery. ,vol. 83, pp. 672- 674 ,(2005) , 10.1002/BJS.1800830526
Blake Cady, Lymph Node Metastases Archives of Surgery. ,vol. 119, pp. 1067- 1072 ,(1984) , 10.1001/ARCHSURG.1984.01390210063014
M. SASAKO, Risk factors for surgical treatment in the Dutch Gastric Cancer Trial British Journal of Surgery. ,vol. 84, pp. 1567- 1571 ,(2005) , 10.1111/J.1365-2168.1997.02842.X
Harold J Wanebo, B.J Kennedy, David P Winchester, Andrew K Stewart, Amy M Fremgen, Role of splenectomy in gastric cancer surgery : adverse effect of elective splenectomy on longterm survival Journal of The American College of Surgeons. ,vol. 185, pp. 177- 184 ,(1997) , 10.1016/S1072-7515(01)00901-2