Role of radiation therapy in gastric adenocarcinoma.

作者: Lisa Hazard

DOI: 10.3748/WJG.V12.I10.1511

关键词: Randomized controlled trialCancerAdjuvantCombined Modality TherapyInternal medicinePalliative careOncologyChemotherapyRadiation therapyMedicineAdenocarcinoma

摘要: Outcomes in patients with gastric cancer the United States remain disappointing, a five-year overall survival rate of approximately 23%. Given high rates local-regional control following surgery, strong rationale exists for use adjuvant radiation therapy. Randomized trials have shown superior local radiotherapy and improved chemoradiation. The benefit chemoradiation who undergone D2 lymph node dissection by an experienced surgeon is not known, therapy addition to chemotherapy continues be defined. In unresectable disease, allows long-term small number provides effective palliation. Most show combined modality compared or alone. The pre-operative, intra-operative, 3D conformal, intensity modulated promising but requires further study. The current article reviews role treatment resectable carcinoma, focusing on recommendations States.

参考文章(60)
Gunther Klautke, Thomas Foitzik, Kaja Ludwig, Peter Ketterer, Ernst Klar, Rainer Fietkau, Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma. Strahlentherapie Und Onkologie. ,vol. 180, pp. 695- 700 ,(2004) , 10.1007/S00066-004-9194-Z
Frank Lohr, Barbara Dobler, Sabine Mai, Brigitte Hermann, Uta Tiefenbacher, Petra Wieland, Volker Steil, Frederik Wenz, Optimization of dose distributions for adjuvant locoregional radiotherapy of gastric cancer by IMRT Strahlentherapie Und Onkologie. ,vol. 179, pp. 557- 563 ,(2003) , 10.1007/S00066-003-1087-Z
Harry Bleiberg, Nicole Duez, Marc Buyse, A. Gerard, Jean Claude Pector, Jeffrey Michel, Alain Roussel, Marc Gignoux, Jean Claude Goffin, G. Samana, Otilia Dalesio, Adjuvant radiotherapy and chemotherapy in resectable gastric cancer. A randomized trial of the gastro-intestinal tract cancer cooperative group of the EORTC. Ejso. ,vol. 15, pp. 535- 543 ,(1989)
J Hermans, J J Bonenkamp, M C Boon, A M Bunt, S Ohyama, M Sasako, C J Van de Velde, Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. Journal of Clinical Oncology. ,vol. 11, pp. 1441- 1447 ,(1993) , 10.1200/JCO.1993.11.8.1441
G. S. Okawara, K. Winter, J. H. Donohue, P. W. T. Pisters, C. H. Crane, J. F. Greskovich, P. R. Anne, J. D. Bradley, C. Willet, J. A. Ajani, A phase II trial of preoperative chemotherapy and chemoradiotherapy for potentially resectable adenocarcinoma of the stomach (RTOG 99–04) Journal of Clinical Oncology. ,vol. 23, pp. 4019- 4019 ,(2005) , 10.1200/JCO.2005.23.16_SUPPL.4019
A M Bunt, J Hermans, V T Smit, C J van de Velde, G J Fleuren, J A Bruijn, Surgical/pathologic-stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. Journal of Clinical Oncology. ,vol. 13, pp. 19- 25 ,(1995) , 10.1200/JCO.1995.13.1.19
Trevor Leong, David Willis, Daryl Lim Joon, Sara Condron, Andrew Hui, Samuel Y.K. Ngan, 3D Conformal radiotherapy for gastric cancer—results of a comparative planning study Radiotherapy and Oncology. ,vol. 74, pp. 301- 306 ,(2005) , 10.1016/J.RADONC.2005.01.006