Perioperative chemotherapy in operable gastric and lower oesophageal cancer: Final results of a randomised, controlled trial (the MAGIC trial, ISRCTN 93793971)

摘要: 4001 Background: Epirubicin, Cisplatin and infused 5-FU (ECF) shows significant benefit in advanced oesophagogastric cancer, particularly locally disease. This trial was designed to determine whether this effect translates into a survival advantage operable Methods: Patients with adenocarcinoma of the stomach, junction or lower oesophagus were randomised perioperative chemotherapy (CSC arm) surgery alone (S arm). In CSC arm, comprised three pre-operative post-operative cycles, 3 weeks apart, E 50mg/m2 IV bolus, C 60mg/m2 infusion 200mg/m2/day continuous infusion. The powered (2α=5%, 1-β=90%) detect 15% increase 5-year (∼250 events required), pre-planned analysis another European same design, collectively giving ∼90% power 10% survival. latter closed early, therefore from MAGIC alone, fi...