Emulsion-Based Adjuvants for Improved Influenza Vaccines

摘要: Emulsions have a long history of use as potent and effective adjuvants in humans for range vaccines, particularly influenza. Although older mineral oil- water-in-oil-based emulsion did not an overall safety tolerability profile to allow them be acceptable widespread use, newer generation oil-in-water has been recently developed, based on the biodegradable oil squalene. These shown particular value development new vaccines offer enhanced protection against both seasonal pandemic strains influenza virus. The first adjuvant included approved flu vaccine was MF59, which originally licensed Europe 1997 improved elderly. In very recent past, MF59 related their by offering possibility significant antigen dose reductions higher potency products face H1N1 emergency other threats. global problem allowed opportunity emulsion-based population groups number countries, strict monitoring norm. Importantly, this squalene-based further substantiated large diverse populations humans, including young children pregnant women. It is our confident prediction that coming years will see wider licensures adjuvants, vaccines.