New preparation of (123I) iodolisuride from the 2-tri-n-butylstannalisuride derivative

摘要: Abstract A simplified and efficient method is described for the preparation of [ 123 I]2-iodolisuride. The radioiodination 3-(9,10-didehydro-6methyl-8a-ergolinyl)-1,1-diethylurea (lisuride) based on tributyltin to I exchange in oxidative conditions. After optimization reaction parameters I]2-iodolisuride was obtained without high performance liquid chromatography purification with radiochemical yields >90% a purity higher than 95%. specific activity product more 500 MBq/nmol. In vitro binding studies striatal membranes ex vivo autoradiography rats showed that I] or 125 prepared using this method, have same radiopharmacological characteristics as radioiodinated iodolisuride Iodogen® method.