Nutrition Intervention Studies of the Esophageal Cancer in Linxian, China

作者: Jun-Yao Li

DOI: 10.1007/978-1-4612-5006-7_21

关键词: Esophageal cancerChinaInternal medicinePopulationCancerOncologyEsophagusIncidence (epidemiology)VitaminMortality rateEnvironmental healthMedicine

摘要: The highest worldwide incidence and mortality for cancer of the esophagus occurs in China.(1,2) Linxian, Henan Province, is epicenter this maligancy may indeed be world’s risk area, where cumulative death rates (0–74yr) are 32.5% males 20.4% females. Reasons such exceptional esophageal not yet known, but a series investigations carried out Linxian suggests that population enhanced susceptibility to specific carcinogens because deficiencies multiple nutrients, especially vitamins minerals. (3,4,5) To test an hypothesis vitamin/mineral contribute Linxian’ s high supplementation reduce risk, Cancer Institute, Chinese Academy Medical Sciences collaboration with National NIH, U.S.A. carring two intervention trials using vitamin-mineral supplements. One trial will conducted patients diagnosed dysplasia other general population.

参考文章(15)
D L Newton, M B Sporn, Chemoprevention of cancer with retinoids. Federation proceedings. ,vol. 38, pp. 2528- 2534 ,(1979)
Chung S. Yang, Research on Esophageal Cancer in China: a Review Cancer Research. ,vol. 40, pp. 2633- 2644 ,(1980)
Curtis Mettlin, Saxon Graham, Roger Priore, James Marshall, Mya Swanson, Diet and cancer of the esophagus Nutrition and Cancer. ,vol. 2, pp. 143- 147 ,(1981) , 10.1080/01635588109513674
R. Peto, R. Doll, J. D. Buckley, M. B. Sporn, Can dietary beta-carotene materially reduce human cancer rates? Nature. ,vol. 290, pp. 201- 208 ,(1981) , 10.1038/290201A0
Jerome M. Blondell, The anticarcinogenic effect of magnesium Medical Hypotheses. ,vol. 6, pp. 863- 871 ,(1980) , 10.1016/0306-9877(80)90010-9
Chung S. Yang, Jian Miao, Wenxian Yang, Mei Huang, Tianyuan Wang, Hongji Xue, Shuheng You, Jianbang Lu, Jinming Wu, Diet and vitamin nutrition of the high esophageal cancer risk population in Linxian, China. Nutrition and Cancer. ,vol. 4, pp. 154- 164 ,(1982) , 10.1080/01635588209513751
N. Muñoz, A. Grassi, Shen Qiong, M. Crespi, Wang Guo Qing, Li Zhang Cai, PRECURSOR LESIONS OF OESOPHAGEAL CANCER IN HIGH-RISK POPULATIONS IN IRAN AND CHINA The Lancet. ,vol. 319, pp. 876- 879 ,(1982) , 10.1016/S0140-6736(82)92151-1
J.-Y. LI, B.-Q. LlU, G.-Y. LI, Z.-J. CHEN, X.-D. SUN, S.-D. RONG, Atlas of Cancer Mortality in the People's Republic of China. An Aid for Cancer Control and Research International Journal of Epidemiology. ,vol. 10, pp. 127- 133 ,(1981) , 10.1093/IJE/10.2.127
Schalk J van Rensburg, Epidemiologic and Dietary Evidence for a Specific Nutritional Predisposition to Esophageal Cancer Journal of the National Cancer Institute. ,vol. 67, pp. 243- 251 ,(1981) , 10.1093/JNCI/67.2.243
Li Jun-Yao, Epidemiology of Esophageal Cancer in China Cancer of the Liver, Esophagus, and Nasopharynx. ,vol. 62, pp. 85- 96 ,(1987) , 10.1007/978-3-642-71510-5_12