Treatment of Narcolepsy with Methamphetamine

摘要: Eight pairs of subjects (each consisting a narcoleptic and control matched on the basis age, sex, educational background job) were evaluated under following double-blind, randomized treatment conditions: baseline, placebo, low dose high methamphetamine. Subjects drug-free for 2 weeks prior to beginning protocol. Methamphetamine was only drug taken during protocol given in single morning 0, 20 or 40-60 mg narcoleptics 5 10 controls. The 28 days long, with each four conditions lasting 4 followed by 3 washout. Nighttime polysomnography daytime testing done last 24 hours condition. Daytime sleep tendency assessed multiple latency test (MSLT). performance tests including simple, computer-based driving task. Narcoleptics' mean MSLT increased from 4.3 minutes placebo 9.3 dose, compared an increase 10.4 17.1 error rate task decreased 2.53% 0.33% decrease 0.22% 0.16% effects methamphetamine nocturnal generally dose-dependent affected continuity rapid eye movement (REM) sleep. Elimination half life estimated be between 15.9 22.0 hours. Mild side emerged fashion most often involved central nervous system gastrointestinal tract. We concluded that caused improvement both at doses allowed function levels comparable those unmedicated