Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.

摘要: Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other pose a significant threat to human health. Majority of these are responsible for the outbreaks pathogenic lethal infections. To date, there no effective therapeutic strategies available prophylaxis treatment Chloroquine analogs have been used decades primary most successful drugs against malaria. Concomitant with emergence chloroquine-resistant Plasmodium strains subsequent decrease in use antimalarial drugs, applications investigated. Since interesting biochemical properties, found be wide variety viral As antiviral action, shown inhibit acidification endosome during events replication infection. Moreover, immunomodulatory effects beneficial patients severe inflammatory complications several diseases. Interestingly, one targeting is inhibition HIV by in vitro which being tested clinical trials. This review focuses on potentialities chloroquine endosomal low pH dependent emerging