Multiscale perspectives of virus entry via endocytosis.

摘要: Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding virus via endocytosis is critically important for the design antiviral strategies. Virus a complex process involving hundreds cellular proteins. The entire dictated by events occurring at multiple time length scales. In this review, we discuss evaluate available means investigate entry, from both experimental theoretical/numerical modeling fronts, highlight importance multiscale features. complexity requires investigations systems biology level, which involves combination different approaches, collaboration experimentalists theorists across disciplines, development novel models.